The game begins with MI6 agent James Bond kidnapping Mr. White, a member of the previously unknown criminal-terrorist organization Quantum. While he and M interrogate White, they are attacked by the traitorous MI6 agent Craig Mitchell, who is killed by Bond while White escapes. Later, Bond spies on a meeting of Quantum members discussing a project called Tierra at the Bregenz Opera House and photographs them; among them is Dominic Greene, the CEO of Greene Planet and a well-known environmentalist.
The game jumps forward to Bond crash landing in Bolivia, where Greene Planet's Project: Tierra was revealed: create artificial dams to block and holding water in a makeshift resovar to prevent it going to Bolivia. By this time, Bond has met Camille Montes, who is seeking vengeance against General Medrano, who is trying to overthrow the Bolivian government. Bond learns that Medrano killed Camille's family, and this is why she wants revenge. Bond opens up to Camille about the death of his former lover Vesper Lynd, recounting his experience during the events of Casino Royale: chasing Mollaka through Madagascar, infiltrating the Miami Science Center to kill Dimitrios, saving Skyfleet from Carlos at Miami International Airport, killing Bliss en route to Montenegro, meeting Vesper, saving Le Chiffre from Steven Obanno and his men at the Casino, saving Vesper from Le Chiffre, and finally confronting Vesper and Gettler in Venice where Vesper dies, at which point the game flashes back to the present.