50 Cent finds himself being dragged back into the criminal underworld, taking on the most dangerous criminal organizations in New York City. 50 Cent gets a call from his former cellmate and friend K Dog, letting him know he is in trouble. 50 Cent gets his gun and leaves, getting his crew together: rappers Lloyd Banks, the locksmith, Young Buck and Tony Yayo, a demolition expert. The crew goes to Queens, where they see K Dog being physically assaulted by unknown masked assailants. After killing multiple assailants, 50 Cent is shot nine times and left for dead. 50 Cent is brought to Doc Friday, a former licensed doctor until he started writing prescriptions for himself. After recovering, 50 Cent goes to Detective Aaron McVicar, a corrupt cop, for information. McVicar agrees to help 50 Cent in exchange for money. 50 Cent and Lloyd Banks go to see K Dog at a safe house, where they run into the same masked men from earlier, who are also there for K-Dog. They discover K Dog as well as the federal prosecutors' corpses. 50 gets K Dog's belongings and brings it back to Bugs, who is able to listen to the messages left on the phone. The messages say K Dog was supposed to meet up with "Spyder", a crystal meth drug dealer about transport routes. 50 decides to go after Spyder and goes to a junkyard to meet up with him. After killing Spyder's assailants along with McVicar, he kills Spyder. They notice a tattoo similar to the one on K Dog. He cuts Spyder's skin with the tattoo on it and gives it to Bugs. The tattoo is traced back toWu-Jang, a Chinese drug kingpin. 50 kills Wu-Jang in Chinatown and takes his money.[1]