Ben 10 Ultimate Alien: Cosmic Destruction introduces the new alien heroes and challenging puzzle elements. Players control Ben Tennyson and up to 16 alien transformations, including Ultimate Big Chill, Ultimate Spidermonkey, Ultimate Echo Echo, Ultimate Swampfire, Ultimate Humungousaur, Four Arms (PS3) and Rath (Xbox 360).
The game involves Ben traveling around the world in search of the parts to an ancient Galvan artifact called the Potis Altiare to save the Earth from total destruction by an evil To'kustar.