Big Mutha Truckers is primarily a racing game, in the same vein as 18 Wheeler: American Pro Trucker. Players spend the majority of their time on the road, navigating the highways between the game's six cities: Salt Sea City, Capital City, Greenback, Skeeter's Creek, Smokestack Heights, and Big Mutha Truckin' Incorporated. The player will earn most of their money through trade, shipping goods from cell phones to beer, with additional opportunities from mini-games and challenge races.