Players move John Constantine in an RPG-like style, collecting ammo, using an item to restore health and casting spells. Gameplay is a type of third-person shooter style, with changing camera views. Players can select from a variety of weapons to eliminate demons. Cutscenes initiate special missions or boss battles when they occur, giving a round of gameplay a different view.
John can cast spells that can create lightning storms, expel demons, create swarms of flies or confuse enemies. Each requires the player to hit a sequence of keys within a small window of time, with John chanting at each keypress. The spells have been described by critics as being unimpressive, without much impact on play, making them feel like a supplement to the other weapons.