In Destroy All Humans! 2, Crypto is able to go to San Francisco (Bay City), London (Albion), a Japanese island loosely based on Tokyo (Takoshima), Siberia (Tunguska), and the Soviet Moon base Solaris. Crypto can now body snatch humans, using them as a disguise.[2] In addition, new weapons are unlocked by finding data cores ejected from the mothership before it was destroyed. New saucer landing points are unlocked by completing the challenges of the ancient Furon god Arkvoodle.[2] The player is now able to call their saucer from an empty landing site in order to eliminate back tracking, and the UFO can now cloak for limited periods of time. In addition, the Abducto Beam actually abducts humans into the UFO for usage in the Gene Blender, which upgrades Crypto's abilities. Destroy All Humans! 2 has a co-op multiplayer mode, so the player can play through the story mode, free roam together and minigames, such as PK Tennis and Duel, with a friend. The new "Free Love" feature enables Crypto to momentarily force his victims to groove to psychedelic music, thus making them forget they saw him. The new ability called "Mind Flash" mentally stuns everyone in the world for a brief period of time. The Jetpack has a longer-lasting battery.[4]
There are 5 new weapons: The Disclocator, which shoots levitating purple disks that take targets with them. The Meteor Strike, which fires up to 3 meteors at the crosshairs, Gastro, the mother ship's former janitor who uploaded himself into a hologram like Pox, who shoots at nearby enemies before self destructing, The Burrow Beast, which shoots out a lure for a giant space worm to crawl around, eating nearby humans, and the Anti-Gravity Field, which creates a small point of high gravity, which pulls anything, including humans, into it before exploding, destroying anything.