Gameplay in Devil May Cry 4 is like previous games in the series. The player must fight through levels called "missions", occasionally solving puzzles or gathering items. Performance in a mission is graded from "D", the lowest grade, to "A" then "S", "SS", and "SSS", the highest grade. Grades are based on items used, Red Orbs gathered, time taken, and the number of Style Points accumulated. Each Style Point grade has its own tag-word. The stylish grade shows up on the side of the screen and begins at "Deadly" (D); progresses through "Carnage" (C), "Brutal" (B), and "Atomic" (A); then, advances through one last bar of grades containing the phrases "Smokin'" (S), "Smokin' Style" (SS), and lastly "Smokin' Sick Style" (SSS). Stylish combat is the focus of the game, conveyed through unbroken combos of varied attacks while avoiding damage. The player must avoid enemy attacks to continue performing combos, often by memorizing attack patterns.[2] The Devil Trigger is a super state that enables the player to become more powerful adding a slow but steady health regeneration, with increased damage done. Devil Trigger can be activated by pressing the button to trigger it when the gauge is filled.[2]
Some changes introduced in Devil May Cry 4 are the presence of two playable characters, Dante and Nero, and a slight modification to the shop system. A new currency, Proud Souls, is used to buy new abilities while Red Orbs are used to buy items. Proud Souls are rewarded at the end of missions; the amount varies depending on how well the player performed. The cost of abilities increases with the purchase of other abilities, though all abilities can be sold back for their original price.[2]