Hitman 2 features mission-based gameplay and is presented from the third-person perspective, which can optionally be switched to a first-person view. On each level, the main character, a contract killer named Agent 47, is given a set of objectives to complete. Most levels require the assassination of one or more people. The way through which the missions are to be completed is up to the player, and there are often a variety of ways to complete missions. Instead of taking an action-oriented, aggressive approach, one can also set traps, like poisoning a drink, to terminate the target in silence. Some missions have assassination possibilities unique to the level.
Agent 47 can find disguises or remove them from an incapacitated person to blend in with his surroundings and access restricted areas. This plays in with the "suspicion" system; a bar beside the health meter on the HUD represents how much suspicion the player garners. There are multiple ways to blend in more effectively; for example, the player can make sure to carry an AK-47 assault rifle while disguised as a Russian soldier. Despite the usage of a uniform, being too near to fellow guards will increase the suspicion as they would have an opportunity to more closely examine Agent 47. Running, climbing and being in restricted places are other ways to garner concern.
Agent 47's cover can be blown if suspicion gets too high, and the disguise will no longer be of any use. It is possible to switch between multiple disguises throughout the level.