A main point of the game focuses on the three types of Mad Sciences. They are mechanical, biological and alchemical. Three portions of the Castle (your HQ) are the three areas of these sciences. They are the Workshop (owned by Professor Fuseless), bio chamber (owned by Dr. Heleena Sonderbar), and arcanium (owned by Brazo De La Sombra).
The mechanical science makes mechanical parts for your monster, they may be gear and steam-powered or shiny and futuristic.
The biological science makes living parts, a lot of plants, and things made of human and animal flesh.
The alchemical science makes (summons) magic parts for your monsters, including undead, elemental, or mythical creature components.
Mechanical attacks are strong against biological parts, biological attacks are strong against alchemical parts, and alchemical attacks are strong against mechanical parts. In order to create parts, you have to collect ingredients from defeated enemies and mini-games. Those ingredients are brought to the labs of one of the three mad scientists where you play mini-games to combine the pieces into either legs, heads, torsos, or arms. You may then create your own controllable monster by combining the parts into a single creature.