Rampage: Total Destruction, as with previous games in the series, has players destroying the environment to earn points. Other actions are available in addition to destroying buildings; people can be eaten and players can also throw vehicles to cause more damage. New to the series is the ability to climb on the front of a building to destroy it. Hidden in each city are tokens which, when eaten, will unlock new characters and special abilities. Playing well fills a character's special meter which can be used to utilize special abilities such as Rampage mode or the Roar power.
Total Destruction features four game modes:
The first is a campaign in which players work to progressively take out cities around the world while following a story. King of the City and King of the World are competitive modes where up to four players (or two in the PlayStation 2 version) compete.
In "King of the City", players strive to rule a city by dominating the most districts.
"King of the World" is a series of King of the City competitions across various cities.
The fourth mode is a time trial mode.