The controls and gameplay are similar to the Resident Evil remake, which was exclusive to the Nintendo GameCube, with quite a few adjustments. The player chooses a scenario, difficulty level, and character selection screen. The difficulty level is tied to what enemies and items the player encounters while progressing through the scenario. The game has five scenarios, each of which has an event checklist consisting of special actions that the player must perform to reach 100% completion. Upon doing so the player will unlock "Infinity Mode", in which all the player's weapons never break or run out of ammunition.
Each scenario also has "SP" items. These are invisible items hidden throughout the level and are randomly generated on two paths[clarification needed]. There are 20 scenario items for each scenario, and twenty items specific to each character hidden across the five scenarios. If acquired, these items unlock new costumes and the option to listen to their ad-libs.