Jericho's core gameplay consists of leading the game's seven-man team codenamed Jericho, allowing control of all team members by jumping to each character during certain points in the game, through various environments that have been warped by the Firstborn while fighting off a variety of twisted creatures.
The game also features several quick time events where the player must press the corresponding buttons or keys shown on screen in order to successfully survive. Additionally, each team member has both a primary and a secondary attack, either in the form of an alternate fire such as a grenade launcher on a rifle, or a secondary weapon such as a sword or pistol that can be dual wielded. While the game is a first-person shooter, the ability to control different members of one's squad adds a tactical element; players must determine which squad member is appropriate for each particular job. Not only does each squad member have different strengths and weaknesses, but they also each have a unique ability (or supernatural abilities in some cases). This allows the player freedom in choosing a playing style that suits them throughout much of the game. However, during certain instances, certain characters are unplayable.