NCAA March Madness 2001 has just about everything that any college basketball fan would ever look for in a videogame representation of the sport. It has everything that was in last year's version, including a comprehensive Dynasty mode, the Women's Sweet 16, a basic tournament, and a Dream Tournament mode that lets players compete in a tournament that features over 60 all-time classic teams, including some of UCLA's legendary teams from the late '60s and early '70s and the University of Michigan team that featured the Fab Five.
What's new to the game is the addition of a Coach K's Coach Mode that's a new option in the game's already extensive Dynasty Mode. The difference with this option turned on is that instead of picking and choosing which team to control, players are randomly given a small school to coach with a different set of goals that must be reached. For instance, players might be given the task of taking the realms of Bethune-Cookman Wildcats with the basic goals of finishing the season with a winning record, winning three conference games, and beating at least one top 25 team or three teams ranked above you in the conference.