The PS3, Wii and PSP versions allow the players to play as Phineas, Ferb, Perry, Agent T, Second Dimension Phineas and Second Dimension Ferb as the major characters while unlocking Isabella, Baljeet, Peter the Panda and Pinky the Chihuahua by collecting tickets from mini games. Players will have the option to work together in two-player cooperative modes while navigating through an old time 1928-style cartoon world, a lawn gnome land, a balloon world, and a gelatin world. In a mission to save the world, players will journey through 25 levels while overcoming obstacles. They also can upgrade new gadgets including the Carbonator, which fires carbonated orange soda that can melt enemies and Ninja Gloves, which allows players to stick to walls. The PlayStation 3 version is the first time a Phineas and Ferb video game features PlayStation Move motion controller compatible gameplay.
In the DS version, Phineas, Ferb, and Perry are playable. There are five worlds with varying level designs totaling 30 levels. Players work to earn gadget upgrades, including a baseball launcher and a grapple gun, while solving environmental puzzles in an effort to save Alternate Danville. The DS version has a significant difference from the previous DS games in the series, as it focuses more on platforming than collecting items.